Membrane associated proteins in eicosanoid and glutathione metabolism (MAPEG) is defined according to enzyme activities, sequence motifs and properties. The family contains six main proteins in human including: FLAP (5-lipoxygenase activation protein), LTC4 synthase, MGST (microsomal glutathione) 1-3 and MGST1-like protein. All of the members have a similar amino length of 150 and have a common 12 times transmembrane structure which display complex interaction in inflammatory stimulus.
