The diabetic foot syndrome is not a homogenous clinical picture and is a sequel of diabetes mellitus. There is a great individual variability of symptoms. The visible and invisible injury of the foot is the causative agent no matter what the underlying factors are. The cause for that is the injury of vessels and nerves due to consistently bad blood sugar levels. The Charcot foot (named after French neurologist Jean Martin Charcot) is a further complication of DFS: it is a neuro-osteopathy and a neuro-osteoarthropathy. It is diagnosed clinically and radiologically. Due to a neuropathy the foot bone dissolves and additionally the nerves degenerate. In the following the skeleton of the foot collapses.