D-amino acids are incorporated or assimilated slower than the L-isomers, that the half-life of antibiotics and medicines containing D-amino acids is longer. D-amino acids are commonly used in semi-synthetic antibiotics synthesis, including traditional and new penicillin core and cephalosporin core antibiotics. For example, using D-Asp and amoxicillin as raw materials, aspoxicillin can be chemically synthesized . Aspoxicillin is popular due to its long half-life and low serum protein-binding characteristics. Compounds and peptides containing D-amino acids are very potent in disease therapy.
