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Cryo-Electron Microscopy (Cryo-EM) techniques have been essential for understanding the structure of biological specimens such as cells, tissues and macromolecular complexes. Characterizing the molecular structure of macromolecules is crucial for getting an insight into understanding of the biochemical and cellular processes. Due to there is not required crystallization and only small amounts of sample are needed, Cryo-EM has become a major technique in structural biology for the studies of functional complexes. Meanwhile, with the advanced of image processing and three-dimensional reconstruction techniques, Cryo-EM can also provide a three-dimensional (3D) maps of biological macromolecules at a near-atomic resolutions.