Illustration of the CB-1 receptor of the Endocannabinoid System. The receptor CB-2 also belongs to the system, but is not depicted here. The CB-1 receptor is primarily found in specific structures of the brain (hippocampus, cerebellum, basal ganglia). They are activated by cannabis, but there are substances that inhibit these receptors. Their functional significance is insufficiently studied. But their location indicates that they may take part in learning and motion processes. It is assumed that the receptor density influences the occurrence of anxiety disorders, pain, sleep, and appetite.