A two-chromatid chromosome is a chromosome that consists of two identical chromatids, the so-called sister chromatids, which are held together by the centromere. During the anaphase of mitosis (cell division) or anaphasis II of meiosis (gamete division), the two chromatids are seperated on the centromere, becoming two one-chromatid chromosomes, that now get arranged at the opposing cell poles. After mitosis, the interphase happens: The one-chromatid chromosomes are reconverted to two-chromatid chromosomes by DNA replication. The result of meiosis are four gametes consisting of each one chromatid with haploid chromosome sets.