The image shows mitotic metaphase (upper) and anaphase (lower) in Drosophila tissue culture cells immunostained for the microtubule severing protein katanin (green), microtubules (red) and kinetochores/chromosomes (blue). Katanin targets to chromosomes during both metaphase and anaphase and is responsible for inducing the depolymerization of attached microtubule plus-ends.
Biological Process: Mitosis
See D. Zhang et al. 2007 Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. J Cell Biol 177, 231-242.
Author: Daniel Buster
Source: The Cell: An Image Library
