Non-Hodgkin's lymphoma manifests itself initially as painless lymph node enlargement (lymphadenopathy). In the course patients shows mild fatigue and decreased energy, B symptoms (fever, night sweats, weight loss) and increased susceptibility to infection.The prognosis varies depending on the NHL-type. Some have very good chances of being cured, but there are also cases that allow only for palliative therapy. Often the patients are hospitalized for a long time. Problematic are concomitant bone marrow failure with anemia, bleeding and susceptibility to infection.