Albendazole Powder is an antiparasitic agent. It's a benzimidazole derivative which provides broad spectrum activity against many trematode and cestode parasites. Pure albendazole powder works by inhibiting the activity of gamma amino butyric acid at GABA receptor sites; this leads to increased chloride conductance and neuronal hyperpolarization within the CNS. At therapeutic doses, albendazol does not cause CNS stimulation or seizures. Albendazole powder priece is rapidly absorbed following oral administration of the drug, with high bioavailability. The drug is mainly distributed to the liver, lungs, and spleen; it's also highly distributed to the renal tubular cells. Albendazol is rapidly metabolized in the liver via hydroxylation followed by glucuronidation and sulfation to form water soluble metabolites which are excreted by the kidneys.
Pure albendazole powder has a half-life of 3 h. Albendazol is well absorbed orally with peak plasma concentrations occurring between 1/2 h post administration (PO). It's easily penetrated across intestinal mucosa and can be found in cerebrospinal fluid (CSF) as early as 10 min after oral administration with . Albendazol is metabolized in the liver by N-demethylation, beta oxidation and hydroxylation followed by glucuronidation and sulfation. It's excreted in the urine as water soluble metabolites with a half life of 3 h.
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