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The Orthokine-Therapy involves the production of an autologous serum, derived from the patients’ blood, containing an increased concentration of anti-inflammatory cytokines. This Autologous Conditioned Serum (ACS) is determined for the safe and effective treatment of osteoarthritis and sciatic pain. The cytokine antagonist interleukin-1 receptor antagonist (IL-1Ra) forms the key, concerning this type of treatment.