Simplified cancer immunology

Every normal cell has the capability to eliminate itself when its DNA is damaged (intrinsic tumour suppression). This, amongst others, to prevent the development of cancer cells. But, sometimes the genes that are involved in intrinsic tumour suppression are damaged, the intrinsic tumour suppression mechanism fails and cancer cells may survive. Chronic inflammation plays a crucial role in the development of the tumour matrix.
The best treatment option is to remove all tumour masses completely by means of radical curative surgery and treatment of the underlying chronic inflammation. Unfortunately, this is not always possible. In these cases, modern cancer therapy consists of: the combination of debulking surgery, treatment of the underlying chronic inflammation, immunotherapy to specifically attack the tumour cells, and immunotherapy to weaken the tumour protection by the tumour matrix.

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